FINAL INTEGRATED PROPOSAL • V10
Project Aqua Pure
A scalable PIC/S-aligned sterile IV manufacturing campus connecting clean utilities, compounding, double-train ISPM blow–fill, terminal sterilization, inspection, packing and controlled logistics.
EXECUTIVE OVERVIEW
One controlled manufacturing chain, designed as a complete operating system.
The proposal consolidates the available master plans, equipment layouts and vendor references into a coordinated basis for design development, tendering, validation planning and regulatory engagement. D3 remains the baseline option; D4 is the strategic double-train configuration with approximately twice nominal production capacity.
PW/WFI→Compounding→ISPM→Autoclave→VIM→Packing
Sheikhupura, Punjab31 km Lahore–Sheikhupura–Faisalabad Road
VISUAL DESIGN RECORD
BTI coordinated image boards
Eleven full-resolution boards arranged as campus, process, utility and logistics chapters.
MASTER-PLAN DECISION
AQI-D3 baseline versus AQI-D4 double-train strategy
D3 • BASELINE
Reference operating configuration
190,780 sq. ft. building reference • 1,188 pallet positions • lower equipment count and simpler initial qualification.
D4 • STRATEGIC GROWTH
Two production trains
138,335 sq. ft. compact building concept • 3,564 pallet positions • duplicated production trains and approximately 2× nominal capacity.
| Decision domain | AQI-D3 | AQI-D4 | Executive implication |
|---|
ENGINEERING BASELINE
Process, clean utilities, HVAC and electrical infrastructure
Verified reference duties presented as proposal assumptions pending detailed vendor and site confirmation.
| System | Design basis | Cleanroom / location | Primary utility |
|---|
READ-ONLY DATA CONSOLIDATION
Site, building and controlled-environment baseline
Missing factual content incorporated from the reference dashboard and reformatted for the independent V10 proposal.
CLEANROOM PRESSURE CASCADE
Grade A → B → C → D
Dedicated hygienic AHUs and DDC control maintain the cascade through production rooms, PALs and MALs.
A+50 PaUDF 0.45 m/s→B+40 Pa45 ACH→C+30 Pa30 ACH→D+15 Pa20 ACH
Street-clothing removal, hair covering, step-over bench, hand wash and HEPA drying, Grade D garment and footwear.
Non-linting jumpsuit, hood, goggles, clean boots and nitrile gloves. No sinks in Grade C.
Sterile jumpsuit, over-boots and sterile gloves through interlocked doors. No sinks in Grade B.
DELIVERY FRAMEWORK
12 master engineering, validation and regulatory packages
One document architecture linking design, procurement, construction, qualification and licensing.
CONSTRUCTION COORDINATION
IFC discipline suites
Six coordinated discipline packages covering structure, electrical, clean utilities, storage, HVAC and cleanroom architecture.
SOURCE CONTROL
Project drawing catalog
18 supplied PDF and DWG references retained as the traceable design basis.
COMMERCIAL READINESS
Seven-division unpriced tender BOQ
Twenty-eight quantified line items covering civil/structural, cleanrooms, process equipment, clean utilities, HVAC/BMS, electrical/backup power and high-density racking.